rap-ah-MY-sin
The most studied longevity compound — activates cellular cleanup by telling your cells to switch from 'growth mode' to 'maintenance mode.'
Also known as: Sirolimus, Rapamune
FDA approved for: Organ transplant rejection prevention · Lymphangioleiomyomatosis
Last reviewed: April 2026
Your cells have a master switch called mTOR that controls whether they focus on growth or maintenance. Modern diets keep mTOR constantly active (growth mode), which accelerates aging. Rapamycin periodically flips the switch to maintenance mode — activating autophagy (cellular cleanup), improving mitochondrial function, and reducing chronic inflammation.
Low-dose capsule taken once weekly with food
Frequency
Once weekly
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
1mg – 6mg weekly
Month 1
No immediate noticeable effects. Cellular changes are occurring.
Month 3
Some report improved skin quality and energy.
Month 6+
Biomarkers of aging may improve. Ongoing autophagy activation.
Overall: Mild
Mouth sores
Canker sores, especially early on. Usually resolve.
Lipid changes
May temporarily raise cholesterol/triglycerides. Monitored via bloodwork.
Delayed wound healing
Pause before planned surgeries.
• Active infections
• Immunocompromised individuals
• Planning surgery (impairs wound healing)
• Pregnancy
• CYP3A4 inhibitors (grapefruit, ketoconazole) — significantly increases rapamycin levels
• Live vaccines — avoid while on rapamycin
• Calcineurin inhibitors — synergistic immunosuppression
Pregnancy: Contraindicated in pregnancy. Effective contraception required during use.
Rapamycin triggers cleanup (autophagy). NAD+ powers energy production. Different mechanisms for the same goal: healthier aging.
NAD+
A coenzyme in every cell that powers your mitochondria — levels drop with age, and restoring them supports energy and cellular repair.
Methylene Blue
One of the oldest synthetic compounds in medicine — boosts mitochondrial energy production and supports cognitive clarity.
MOTS-c
A peptide encoded by your mitochondrial DNA that acts as an exercise mimetic — activating the same pathways as a workout.
Interested? A licensed provider will evaluate if this is appropriate for you.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.