METH-ih-leen blue
One of the oldest synthetic compounds in medicine — boosts mitochondrial energy production and supports cognitive clarity.
Also known as: Methylthioninium Chloride
FDA approved for: Methemoglobinemia treatment · Surgical dye
Last reviewed: April 2026
Methylene blue acts as an electron shuttle in your mitochondria. When your cells' power plants are sluggish, it provides an alternate pathway to keep energy production flowing. At low doses, it enhances cognitive clarity, supports neuroprotection, and acts as an antioxidant.
Low-dose capsule taken in the morning
Frequency
Daily
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
0.5mg – 10mg
Day 1
Some notice improved focus within hours. Urine turns blue-green (harmless).
Week 2–4
Sustained cognitive benefits. Better mental endurance.
Month 2+
Ongoing neuroprotective and mitochondrial support.
Overall: Mild to Moderate
Blue-green urine
Completely harmless — this is expected.
Blue tongue/lips
Temporary discoloration. Cosmetic only.
GI upset
Nausea at higher doses.
Serotonin syndrome
Only if combined with SSRIs/MAOIs. NEVER combine.
Call your doctor if you experience this.
• Taking SSRIs or MAOIs (risk of serotonin syndrome)
• G6PD deficiency
• Renal impairment
• Pregnancy
• SSRIs — DANGEROUS: risk of serotonin syndrome
• MAOIs — DANGEROUS: risk of serotonin syndrome
• Serotonergic drugs — do not combine
Pregnancy: Do not use during pregnancy. May cause fetal hemolytic anemia.
All three support mitochondrial function through different mechanisms. Methylene blue is the electron shuttle, NAD+ is the energy currency, rapamycin triggers cleanup.
NAD+
A coenzyme in every cell that powers your mitochondria — levels drop with age, and restoring them supports energy and cellular repair.
Rapamycin
The most studied longevity compound — activates cellular cleanup by telling your cells to switch from 'growth mode' to 'maintenance mode.'
Interested? A licensed provider will evaluate if this is appropriate for you.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.