P-T one-forty-one / brem-el-AN-oh-tide
A peptide that increases sexual desire by acting on the brain — works differently from ED medications that only improve blood flow.
Also known as: Bremelanotide, Vyleesi
FDA approved for: Hypoactive sexual desire disorder in premenopausal women (Vyleesi)
Last reviewed: April 2026
Unlike Viagra/Cialis which improve the physical mechanics of arousal, PT-141 works in your brain. It activates melanocortin receptors that regulate sexual desire. The result is increased libido and arousal — the 'wanting,' not just the 'functioning.'
Injection into belly fat, taken 45 minutes before anticipated activity
Frequency
As needed (max 8 doses/month)
Pain Level
●○○ Minimal
Self-Administered
Yes — at home
Typical Range
1.75mg
Nasal spray formulation (compounded)
Frequency
As needed
Pain Level
○○○ None
Self-Administered
Yes — at home
Typical Range
Varies
30–45 minutes
Effects begin — increased desire and sensitivity.
2–6 hours
Peak effects. Duration varies by individual.
Up to 12 hours
Residual effects may persist.
Overall: Mild
Nausea
The most common side effect. Anti-nausea medication may help.
Flushing
Facial flushing and warmth.
Headache
Usually resolves within hours.
Blood pressure increase
Temporary rise in blood pressure.
• Uncontrolled hypertension
• Cardiovascular disease
• Not for daily use
• Blood pressure medications — PT-141 may transiently increase BP
• Naltrexone — may reduce effectiveness
Pregnancy: Do not use during pregnancy.
PT-141 targets desire (brain). Sildenafil/tadalafil target function (blood flow). They can be combined for comprehensive support.
Sildenafil
The original erectile dysfunction medication — relaxes blood vessels to improve blood flow when aroused.
Tadalafil
A long-acting ED medication that can last up to 36 hours — also used daily at low doses for ongoing support.
Interested? A licensed provider will evaluate if this is appropriate for you.
Coming Soon →This is a compounded medication prescribed off-label. It has not been FDA-approved for the uses described. All prescribing decisions are made by your independent licensed provider.