NAD+
A critical coenzyme in every living cell that declines with age and is central to energy metabolism and DNA repair.
Also known as: Nicotinamide adenine dinucleotide, NAD, Coenzyme I
Regulatory Status
Classification date: 2024-01-15
Compounding: Legal through licensed 503A/503B pharmacies
Evidence Summary
Key Studies
How It Works
NAD+ serves as an electron carrier in mitochondrial oxidative phosphorylation and is a required substrate for sirtuins (SIRT1-7) and PARPs, enzymes essential for DNA repair, gene silencing, and circadian rhythm regulation. Cellular NAD+ levels decline roughly 50% between ages 40 and 60, contributing to mitochondrial dysfunction. Exogenous supplementation or IV infusion aims to restore these levels and reactivate sirtuin-mediated protective pathways.
Common Applications
Safety & Considerations
IV NAD+ infusions can cause chest tightness, nausea, and cramping during administration; slowing the infusion rate typically resolves symptoms. Oral precursors (NMN, NR) are generally well tolerated. Long-term safety data for high-dose IV NAD+ remain limited. Patients with cancer should consult their oncologist, as NAD+ may theoretically support rapidly dividing cells.
Available Through Our Network
This peptide is available through our partner pharmacies with a valid prescription.
Coming Soon →Regulatory classifications can change rapidly. The information shown here was last verified on 2024-01-15. Always confirm current legal status with a licensed provider or the FDA before making treatment decisions.