Kisspeptin-10
A hypothalamic neuropeptide that acts as the master upstream regulator of the reproductive hormone cascade by stimulating GnRH neurons.
Also known as: KP-10, Metastin 45-54, KISS1 peptide
Regulatory Status
Classification date: 2026-02-27
Reclassification to Category 1 announced but not yet formalized
Compounding: Not currently available for compounding
Evidence Summary
How It Works
Kisspeptin-10 is the bioactive decapeptide fragment of the KISS1 gene product. It binds to the KISS1R (GPR54) receptor on hypothalamic GnRH neurons, triggering pulsatile GnRH release and subsequently LH and FSH secretion. It is the primary physiologic activator of puberty and the menstrual cycle. Exogenous kisspeptin administration can potently stimulate gonadotropin release and is being investigated for IVF trigger protocols and hypogonadism treatment as a more physiologic alternative to hCG.
Common Applications
Safety & Considerations
Well tolerated in human studies. Common side effects include warmth and flushing at the injection site. No ovarian hyperstimulation syndrome (OHSS) reported in IVF studies, which is a significant advantage over hCG triggers. Short half-life (minutes) limits duration of any adverse effects. Currently not legal for compounding in the US.
Related Research
Regulatory classifications can change rapidly. The information shown here was last verified on 2026-02-27. Always confirm current legal status with a licensed provider or the FDA before making treatment decisions.