Gonadorelin

A synthetic gonadotropin-releasing hormone used to stimulate LH and FSH production for fertility and hormonal support.

Also known as: GnRH, LHRH, Factrel, Lutrepulse

Regulatory Status

Legal to Compound

Classification date: 2024-01-15

Compounding: Legal through licensed 503A/503B pharmacies

Evidence Summary

Strong40 human studies published

Key Studies

Pulsatile GnRH therapy for induction of ovulation in hypogonadotropic hypogonadism
Low-dose human chorionic gonadotropin and gonadorelin to maintain spermatogenesis during TRT
GnRH agonists and antagonists in reproductive medicine: mechanisms and clinical applications

How It Works

Gonadorelin is a synthetic decapeptide identical to endogenous GnRH. Pulsatile administration stimulates the anterior pituitary to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), maintaining the hypothalamic-pituitary-gonadal axis. It is commonly used alongside testosterone replacement therapy to preserve testicular function, spermatogenesis, and intratesticular testosterone levels that exogenous testosterone alone would suppress.

Common Applications

Preservation of fertility during TRTDiagnostic evaluation of pituitary functionHypogonadotropic hypogonadism treatmentPost-cycle endocrine recovery supportSupport for endogenous testosterone production

Safety & Considerations

Well tolerated at standard doses. Side effects may include headache, nausea, light-headedness, and injection-site irritation. Continuous (non-pulsatile) administration paradoxically suppresses gonadotropins. Not appropriate for patients with pituitary tumors or hormone-sensitive cancers without specialist oversight.

Available Through Our Network

This peptide is available through our partner pharmacies with a valid prescription.

Coming Soon →

Regulatory classifications can change rapidly. The information shown here was last verified on 2024-01-15. Always confirm current legal status with a licensed provider or the FDA before making treatment decisions.