Glutathione

The body's master antioxidant — a tripeptide critical for detoxification, immune defense, and protection against oxidative stress.

Also known as: GSH, L-Glutathione, Gamma-glutamylcysteinylglycine

Regulatory Status

Legal to Compound

Classification date: 2024-01-15

Compounding: Legal through licensed 503A/503B pharmacies

Evidence Summary

Moderate25 human studies published

Key Studies

How It Works

Glutathione is a tripeptide (glutamate-cysteine-glycine) synthesized in every cell, with the highest concentrations in the liver. It directly neutralizes reactive oxygen species, regenerates vitamins C and E, and serves as a cofactor for glutathione peroxidase and glutathione S-transferase enzymes involved in phase II detoxification. Depletion of glutathione is implicated in neurodegenerative diseases, liver disease, and accelerated aging, making repletion a target for broad-spectrum health optimization.

Common Applications

Antioxidant and detoxification supportLiver health and protectionImmune system modulationSkin brightening and hyperpigmentation reductionAdjunctive support in chronic illness

Safety & Considerations

IV and nebulized glutathione are generally well tolerated. Mild side effects include bloating, cramping, and rare allergic reactions. Inhaled glutathione may exacerbate bronchospasm in asthmatics. Long-term high-dose use has not been extensively studied. Oral bioavailability is limited; liposomal or IV routes are preferred for therapeutic dosing.

Available Through Our Network

This peptide is available through our partner pharmacies with a valid prescription.

Coming Soon →

Regulatory classifications can change rapidly. The information shown here was last verified on 2024-01-15. Always confirm current legal status with a licensed provider or the FDA before making treatment decisions.