GHK-Cu
A naturally occurring copper-binding tripeptide that promotes wound healing, collagen synthesis, and tissue remodeling.
Also known as: Copper peptide GHK, Glycyl-L-histidyl-L-lysine copper, Loren Pickart copper peptide
Regulatory Status
Classification date: 2026-02-27
Reclassification to Category 1 announced but not yet formalized
Compounding: Not currently available for compounding
Evidence Summary
How It Works
GHK-Cu is a tripeptide-copper complex found in human plasma, saliva, and urine whose concentration declines significantly with age. It stimulates collagen and glycosaminoglycan synthesis, promotes angiogenesis, and activates tissue remodeling by recruiting mast cells and macrophages. Genomic studies show GHK-Cu modulates the expression of over 4,000 genes, resetting many toward a healthier profile associated with younger tissue function.
Common Applications
Safety & Considerations
Topical GHK-Cu has an excellent safety profile with decades of cosmetic use. Subcutaneous injection is less studied but generally well tolerated. Rare reports of localized irritation at injection sites. Not recommended for individuals with copper metabolism disorders such as Wilson disease.
Available Through Our Network
This peptide is available through our partner pharmacies with a valid prescription.
Coming Soon →Related Research
Regulatory classifications can change rapidly. The information shown here was last verified on 2026-02-27. Always confirm current legal status with a licensed provider or the FDA before making treatment decisions.