Epitalon
A synthetic tetrapeptide based on the pineal gland's epithalamin that activates telomerase and may slow cellular aging.
Also known as: Epithalon, Epithalone, AGAG, Ala-Glu-Asp-Gly
Regulatory Status
Classification date: 2026-02-27
Reclassification to Category 1 announced but not yet formalized
Compounding: Not currently available for compounding
Evidence Summary
How It Works
Epitalon is a synthetic version of epithalamin, a peptide extract from the bovine pineal gland studied extensively by Vladimir Khavinson. It activates telomerase, the enzyme responsible for maintaining telomere length, in human somatic cells. Telomere shortening is a hallmark of cellular aging, and telomerase activation can extend the replicative capacity of cells. Epitalon also regulates melatonin production, restores circadian rhythm function, and has shown lifespan extension in multiple animal models.
Common Applications
Safety & Considerations
No significant adverse effects reported in available studies. Most research is from Russian institutions with limited Western replication. Theoretical concerns about telomerase activation in cancer cells exist, though no evidence of tumor promotion has been reported. Long-term human safety data is sparse. Currently not legal for compounding in the US.
Related Research
Regulatory classifications can change rapidly. The information shown here was last verified on 2026-02-27. Always confirm current legal status with a licensed provider or the FDA before making treatment decisions.