The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review
The aim of the present review is to discuss the roles of vitamin K (phylloquinone or menaquinones) and vitamin K-dependent proteins, and the combined action of the vitamins K and D, for the maintenance of bone health. The most relevant vitamin K-d...
Aaseth JO, Finnes TE, Askim M et al. — Nutrients
Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review
Osteoporosis, a metabolic bone disorder characterized by decreased bone mass per unit volume, poses a significant global health burden due to its association with heightened fracture risk and adverse impacts on patients' quality of life. This revi...
Elahmer NR, Wong SK, Mohamed N et al. — Biomedicines
Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
Sarcopenic obesity, low muscle mass, and high body fat are growing health concerns in the aging population. This review highlights the need for standardized criteria and explores nutraceuticals as potential therapeutic agents. Sarcopenic obesity i...
Kim YC, Ki SW, Kim H et al. — Nutrients
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial
Vitamin K deficiency is highly prevalent in patients on dialysis and may contribute to their low bone mineral density (BMD) and increased risk of fracture. This study investigated the effect of menaquinone-7 (MK-7) supplementation on BMD in patien...
Levy-Schousboe K, Marckmann P, Frimodt-Møller M et al. — Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Role of vitamins beyond vitamin D3 in bone health and osteoporosis (Review)
The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological fin...
Skalny AV, Aschner M, Tsatsakis A et al. — International journal of molecular medicine
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials
Vitamin K (VK) as a nutrient, is a cofactor in the carboxylation of osteocalcin (OC), which can bind with hydroxyapatite to promote bone mineralization and increase bone strength. However, some studies have been inconsistent on whether vitamin K2 ...
Ma ML, Ma ZJ, He YL et al. — Frontiers in public health
The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials
Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality.
Kuang X, Liu C, Guo X et al. — Food & function
Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health
Supplementation with calcium (Ca) and/or vitamin D (vitD) is key to the management of osteoporosis. Other supplements like vitamin K2 (VitK2) and magnesium (Mg) could contribute to the maintenance of skeletal health. This narrative review summariz...
Capozzi A, Scambia G, Lello S — Maturitas
Vitamin K and bone health
Vitamin K has been purported to play an important role in bone health. It is required for the gamma-carboxylation of osteocalcin (the most abundant noncollagenous protein in bone), making osteocalcin functional. There are 2 main forms (vitamin K1 ...
Hamidi MS, Gajic-Veljanoski O, Cheung AM — Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis
The effect of the combined administration of vitamin D3 and vitamin K2 on bone mineral density (BMD) of the lumbar spine was examined in postmenopausal women with osteoporosis. Ninety-two osteoporotic women who were more than 5 years after menopau...
Iwamoto J, Takeda T, Ichimura S — Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association