Aging and Thymosin Alpha-1
Aging is characterized by immune decline, mainly due to thymic involution-the age-related shrinkage of the thymus gland. This leads to reduced T-cell production, chronic inflammation, and increased susceptibility to age-related diseases. Thymosin ...
Simonova MA, Ivanov I, Shoshina NS et al. — International journal of molecular sciences
Comprehensive Review of the Safety and Efficacy of Thymosin Alpha 1 in Human Clinical Trials
This study aims to assess the safety and efficacy of Thymosin Alpha 1 (Tα1) through a comprehensive narrative review of clinical studies involving over 11 000 human subjects in more than 30 trials. The focus was on Tα1's application in...
Dinetz E, Lee E — Alternative therapies in health and medicine
Phenotypic drug discovery: a case for thymosin alpha-1
Phenotypic drug discovery (PDD) involves screening compounds for their effects on cells, tissues, or whole organisms without necessarily understanding the underlying molecular targets. PDD differs from target-based strategies as it does not requir...
Garaci E, Paci M, Matteucci C et al. — Frontiers in medicine
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression
Effort to search for the optimal COVID-19 treatment has continuously been attempted. Thymosin alpha-1 have immunomodulatory properties which may be beneficial in case of viral infection. This study's goal is to determine whether thymosin alpha-1 i...
Soeroto AY, Suryadinata H, Yanto TA et al. — Inflammopharmacology
Efficacy of Thymosin Alpha 1 in the Treatment of COVID-19: A Multicenter Cohort Study
Thymosin alpha 1 (Tα1) is widely used to treat patients with COVID-19 in China; however, its efficacy remains unclear. This study aimed to explore the efficacy of Tα1 as a COVID-19 therapy.
Liu J, Shen Y, Wen Z et al. — Frontiers in immunology
Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity
Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymos...
Armirotti A, Tomati V, Matthes E et al. — Scientific reports
Serum thymosin alpha 1 levels in normal and pathological conditions
Thymosin alpha 1 (Ta1) is a natural occurring peptide hormone that is crucial for the maintenance of the organism homeostasis. It has been chemically synthesized and used in diseases where the immune system is hindered or malfunctioning.
Pica F, Gaziano R, Casalinuovo IA et al. — Expert opinion on biological therapy
Immune Modulation with Thymosin Alpha 1 Treatment
Thymosin alpha 1 (Ta1) is a peptide originally isolated from thymic tissue as the compound responsible for restoring immune function to thymectomized mice. Ta1 has a pleiotropic mechanism of action, affecting multiple immune cell subsets that are ...
King R, Tuthill C — Vitamins and hormones
Historical review of thymosin α 1 in infectious diseases
Thymosin α 1 (Tα1) is a peptidic biological response modifier, which plays a significant role in activating and regulating various cells of the immune system. For the above-mentioned activities it is expected to exert a clinical benefi...
Camerini R, Garaci E — Expert opinion on biological therapy
Thymosin alpha-1
The pharmacology, pharmacokinetics, clinical efficacy, adverse effects, and dosage and administration of thymosin alpha-1 (TA1) are reviewed. TA1 is a synthetic polypeptide. The drug is in Phase III trials for the treatment of hepatitis C and in P...
Ancell CD, Phipps J, Young L — American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists