Identification of glutamine as a potential therapeutic target in dry eye disease
Dry eye disease (DED) is a prevalent inflammatory condition significantly impacting quality of life, yet lacks effective pharmacological therapies. Herein, we proposed a novel approach to modulate the inflammation through metabolic remodeling, thu...
Chen X, Zhang C, Peng F et al. — Signal transduction and targeted therapy
Mechanistic study of the Tβ4/SLC7A11 signaling pathway regulating breast cancer evolution
Thymosin β4 (Tβ4) plays a critical role in breast cancer progression, yet its molecular mechanism remains unclear. In this study, we identified that Tβ4 is significantly upregulated in breast cancer tissues and cell lines, and it...
Jin Z, Li H, Li J et al. — Cellular signalling
Plasmacytoid dendritic cells alleviate allergic asthma via airway epithelial cell-dependent thymosin β4 expression
Plasmacytoid dendritic cells (pDCs) have been previously reported to induce immune tolerance to allergen by inhibiting allergic TH2-cell priming. However, there is limited knowledge on pDC function during the TH2 effector phase of allergic asthma.
Li Y, Chen Z, Han M et al. — The Journal of allergy and clinical immunology
Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization
Currently, stem cell transplantations in cardiac repair are limited owing to disadvantages, such as immunological rejection and poor cell viability. Although direct injection of exosomes can have a curative effect similar to that of stem cell tran...
Chen P, Ning X, Li W et al. — Bioactive materials
The Role of Tβ4-POP-Ac-SDKP Axis in Organ Fibrosis
Fibrosis is a pathological process in which parenchymal cells are necrotic and excess extracellular matrix (ECM) is accumulated due to dysregulation of tissue injury repair. Thymosin β4 (Tβ4) is a 43 amino acid multifunctional polypept...
Wang W, Jia W, Zhang C — International journal of molecular sciences
Generation of Tβ4 knock-in Cashmere goat using CRISPR/Cas9
The cashmere goat breed is known to provide excellent quality cashmere. Here, we attempted to breed high-yielding cashmere goats by specifically inserting the Tβ4 gene into the goat CCR5 locus and provided an animal model for future research...
Li X, Hao F, Hu X et al. — International journal of biological sciences
The role of Thymosin β4 in angiotensin II-induced cardiomyocytes growth
Thymosin beta-4 (Tβ4) is an actin sequestering protein and is furthermore involved in diverse biological processes including cell proliferation, differentiation, wound healing, stem- or progenitor cell differentiation, and modulates inflamma...
Gupta S, Li L — Expert opinion on biological therapy
Cardioprotection by Thymosin Beta 4
Treatment with thymosin beta 4 (Tβ4) reduces infarct volume and preserves cardiac function in preclinical models of cardiac ischemic injury. These effects stem in part from decreased infarct size, but additional benefits are likely due to sp...
Pipes GT, Yang J — Vitamins and hormones
Function of Thymosin Beta-4 in Ethanol-Induced Microglial Activation
Neuroinflammation mediated by activated microglia may play a pivotal role in a variety of central nervous system (CNS) pathologic conditions, including ethanol-induced neurotoxicity. The purpose of this study was to investigate the function of T&#...
Zhang J, Wu J, Zeng W et al. — Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Increases in plasma Tβ4 after intracardiac cell therapy in chronic ischemic heart failure is associated with symptomatic improvement
Tβ4 is an integral factor in repair of myocardium in animal models. To investigate whether Tβ4 is important in human cardiac disease and has a role in mediating the beneficial cardiac effects of bone-marrow-derived stem cell (BMSC) the...
Choudry FA, Yeo C, Mozid A et al. — Regenerative medicine
Potential role of thymosin Beta 4 in liver fibrosis
Liver fibrosis, the main characteristic of chronic liver diseases, is strongly associated with the activation of hepatic stellate cells (HSCs), which are responsible for extracellular matrix production. As such, investigating the effective regulat...
Kim J, Jung Y — International journal of molecular sciences
The beta-thymosin enigma
Actin dynamics in nonmuscle cells is controlled by the availability of actin nucleating sites and actin monomers. Thymosin beta-4 (Tbeta-4) has been implicated in modulating the availability of actin monomers in a large variety of cells. It togeth...
Sun HQ, Yin HL — Annals of the New York Academy of Sciences