The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress
It was previously thought that inflammation and an immune response were the only factors capable of causing IL-1β, IL-6 and other cytokine`s production. In recent years data have appeared that stressful effects can also occupy an important p...
Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA et al. — Current reviews in clinical and experimental pharmacology
Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank
We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 μg/kg 15 min before stress exposure. In rats subjected ...
Mukhina AY, Mishina ES, Bobyntsev II et al. — Bulletin of experimental biology and medicine
Effect of Selank on Morphological Parameters of Rat Liver in Chronic Foot-Shock Stress
We studied the effects of Selank on morphological parameters of the liver in Wistar male rats subjected to chronic foot-shock stress. Selank was injected intraperitoneally in doses of 100, 300 and 1000 μg/kg 15 min before each stress session...
Fomenko EV, Bobyntsev II, Ivanov AV et al. — Bulletin of experimental biology and medicine
State of Colon Microbiota in Rats during Chronic Restraint Stress and Selank Treatment
We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 μg/kg 15 min before stress exposure. Chronic restraint str...
Mukhina AY, Medvedeva OA, Svishcheva MV et al. — Bulletin of experimental biology and medicine
Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
Anxiety and mood disorders are the most abundant mental health problems worldwide. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor system activity. As a rule, their use presents a...
Vyunova TV, Andreeva L, Shevchenko K et al. — Protein and peptide letters
[COMPARISON OF PHARMACOLOGICAL EFFECTS OF HEPTAPEPTIDE SELANK AFTER INTRANASAL AND INTRAPERITONEAL ADMINISTRATION TO BALB/c AND C57BL/6 MICE.]
Pharmacological effects of intraperitoneal (i.p.) and intranasal (i.n.) administration of heptapeptide selank (300 μg/kg/day for 5 days), known to possess anxiolytic and nootropic properties, were compared by studying the elevated-plus-maze ...
Vasil'eva EV, Kondrakhin EA, Salimov RM et al. — Eksperimental'naia i klinicheskaia farmakologiia
[Optimization of the treatment of anxiety disorders with selank]
To compare the efficacy and tolerability of monotherapy with phenazepam to complex treatment with the peptide preparation selank and phenazepam in patients with anxiety disorders.
Medvedev VE, Tereshchenko ON, Kost NV et al. — Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action
Previous studies have shown that synthetic tuftsin analogue Selank and its fragments cause a number of alterations in the expression of certain genes involved in inflammation in mouse spleen. In this work we studied the effect of Selank and its sh...
Kolomin T, Morozova M, Volkova A et al. — Molecular immunology