Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Pulmonary fibrosis results from persistent and pathological tissue repair, which is therapeutically challenging to attenuate and often fatal. The immune processes involved in fibrosis remain ill defined. Using a bleomycin-induced lung fibrosis mur...
Hiroki CH, Hassanabad MF, Defaye M et al. — Immunity
Peptide-driven approaches in advanced wound healing materials
Peptide-based materials, such as antimicrobial peptides (AMPs), cell-penetrating peptides (CPPs), angiogenic peptides, and extracellular matrix (ECM)-mimetic peptides, offer unique multifunctional benefits for wound healing, including infection co...
Zhang C, Meng L, Sethi G et al. — Drug discovery today
A Frog Skin-Derived Peptide Targeting SCD1 Exerts Radioprotective Effects Against Skin Injury by Inhibiting STING-Mediated Inflammation
The extensive application of nuclear technology has increased the potential of uncontrolled radiation exposure to the public. Since skin is the largest organ, radiation-induced skin injury remains a serious medical concern. Organisms evolutionally...
Geng F, Zhong L, Yang T et al. — Advanced science (Weinheim, Baden-Wurttemberg, Germany)
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective1,2. This is particularly relevant when immune dysregulation that results from conditio...
Lu YZ, Nayer B, Singh SK et al. — Nature
Biomaterials for immunomodulation in wound healing
The substantial economic impact of non-healing wounds, scarring, and burns stemming from skin injuries is evident, resulting in a financial burden on both patients and the healthcare system. This review paper provides an overview of the skin's vit...
Wang Y, Vizely K, Li CY et al. — Regenerative biomaterials
3D-bioprinted peptide coupling patches for wound healing
Chronic wounds caused by severe trauma remain a serious challenge for clinical treatment. In this study, we developed a novel angiogenic 3D-bioprinted peptide patch to improve skin wound healing. The 3D-bioprinted technology can fabricate individu...
Guan G, Qizhuang Lv S, Liu Z et al. — Materials today. Bio
In-situ wound healing by SDF-1-mimic peptide-loaded click crosslinked hyaluronic acid scaffold
Endogenous stem cell-based in-situ tissue regeneration has recently gained considerable attention. In this study, we investigated the potential of a chemokine, SDF-1-mimic peptide (SMP), to promote endogenous stem cell-based in-situ wound healing....
Kim YH, Kim S, Ju HJ et al. — Journal of controlled release : official journal of the Controlled Release Society
Systemically administered wound-homing peptide accelerates wound healing by modulating syndecan-4 function
CAR (CARSKNKDC) is a wound-homing peptide that recognises angiogenic neovessels. Here we discover that systemically administered CAR peptide has inherent ability to promote wound healing: wounds close and re-epithelialise faster in CAR-treated mal...
Maldonado H, Savage BD, Barker HR et al. — Nature communications
MAIT cells in immune-mediated tissue injury and repair
Mucosal-associated invariant T (MAIT) cells are T cells that express a semi-invariant αβ T-cell receptor (TCR), recognizing non-peptide antigens, such as microbial-derived vitamin B2 metabolites, presented by the nonpolymorphic MHC cla...
Waterhölter A, Wunderlich M, Turner JE — European journal of immunology
Synthetic peptide hydrogels as 3D scaffolds for tissue engineering
The regeneration of tissues and organs poses an immense challenge due to the extreme complexity in the research work involved. Despite the tissue engineering approach being considered as a promising strategy for more than two decades, a key issue ...
Ding X, Zhao H, Li Y et al. — Advanced drug delivery reviews
Crafting Polymeric and Peptidic Hydrogels for Improved Wound Healing
Wound healing is a multifaceted biological process involving the replacement of damaged tissues and cellular structures, restoring the skin barrier's function, and maintaining internal homeostasis. Over the past two decades, numerous approaches ar...
Stern D, Cui H — Advanced healthcare materials
Connexin 43-Based Therapeutics for Dermal Wound Healing
The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of interest for modulating the dermal wound healing response. Observational studies found associations between Cx43 at the wound edge and poor healing respon...
Montgomery J, Ghatnekar GS, Grek CL et al. — International journal of molecular sciences