The Safety and Efficacy of Glucosamine and/or Chondroitin in Humans: A Systematic Review
Glucosamine and chondroitin are natural substances often used alone or in combination for conditions affecting the joints. Our objective was to evaluate the efficacy and safety of glucosamine and/or chondroitin supplementation in humans as well as...
Baden KER, Hoeksema SL, Gibson N et al. — Nutrients
Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis
Though glucosamine and chondroitin have become common practices for treating knee osteoarthritis, the clinical value of these two drugs in combination are still questionable. To evaluate the efficacy and safety of the combination of glucosamine (G...
Meng Z, Liu J, Zhou N — Archives of orthopaedic and trauma surgery
Glucosamine and chondroitin for the treatment of osteoarthritis
The prevalence of primary or idiopathic osteoarthritis (OA) of knee and hip joints has substantially increased in general population during the last decades. Analgesics and non-steroidal anti-inflammatory drugs are currently extensively used as no...
Vasiliadis HS, Tsikopoulos K — World journal of orthopedics
Glucosamine and chondroitin use in canines for osteoarthritis: A review
Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine's quality of life, level of comfort, ...
Bhathal A, Spryszak M, Louizos C et al. — Open veterinary journal
Chondroitin Sulfate Safety and Quality
The industrial production of chondroitin sulfate (CS) uses animal tissue sources as raw material derived from different terrestrial or marine species of animals. CS possesses a heterogeneous structure and physical-chemical profile in different spe...
Volpi N — Molecules (Basel, Switzerland)
Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials
To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine.
Zhu X, Sang L, Wu D et al. — Journal of orthopaedic surgery and research
Is glucosamine effective for osteoarthritis?
Osteoarthritis is the most prevalent chronic articular disease, in which pain is one of the main symptoms and a major determinant of functional loss. Several therapeutic options have been proposed, including glucosamine, but its actual usefulness ...
Harrison-Muñoz S, Rojas-Briones V, Irarrázaval S — Medwave
Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib
To compare the efficacy and safety of chondroitin sulfate plus glucosamine hydrochloride (CS+GH) versus celecoxib in patients with knee osteoarthritis and severe pain.
Hochberg MC, Martel-Pelletier J, Monfort J et al. — Annals of the rheumatic diseases
Glucosamine/chondroitin/primorine combination therapy for osteoarthritis
Osteoarthritis (OA) is the most common arthritis affecting the aging population. This degenerative disease can cause significant pain and functional disability in affected individuals. Despite advances in the retardation of rheumatoid arthritis wi...
Fox BA, Stephens MM — Drugs of today (Barcelona, Spain : 1998)
Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis
Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment f...
Clegg DO, Reda DJ, Harris CL et al. — The New England journal of medicine