Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
Epitalon, a naturally occurring tetrapeptide, is known for its anti-aging effects on mammalian cells. This happens through the induction of telomerase enzyme activity, resulting in the extension of telomere length. A strong link exists between tel...
Al-Dulaimi S, Thomas R, Matta S et al. — Biogerontology
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide, Ala-Glu-Asp-Gly (AEDG), which was synthesized based on the amino acids composition of Epithalamin, a bovine pineal gland extract, prior to its discovery in pineal gland polypeptid...
Araj SK, Brzezik J, Mądra-Gackowska K et al. — International journal of molecular sciences
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Diabetic retinopathy (DR) is the most common complication of diabetes mellitus and a leading cause of vision loss. Short peptides, such as di-, tri-, and tetrapeptides, have various beneficial activities, including antioxidant, antimicrobial, and ...
Gatta M, Dovizio M, Milillo C et al. — Stem cell reviews and reports
AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and decreases experimental cancerogenesis. AEDG peptide induces neuronal ...
Khavinson V, Diomede F, Mironova E et al. — Molecules (Basel, Switzerland)
Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
The potential preventive effect of the synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on spontaneous tumorigenesis in mice was studied. One-year-old female C3H/He mice were kept for 6.5 months under standard conditions. Epitalon was injected ...
Kossoy G, Anisimov VN, Ben-Hur H et al. — In vivo (Athens, Greece)
Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress
The aim of this research consisted in studying the effects of tetrapeptide Epitalon on both thymocyte proliferation and interleukin-1beta (IL-1beta) signal transduction via sphingomyelin pathway in the cerebral cortex membranes of mice exposed to ...
Khavinson VKh, Korneva EA, Malinin VV et al. — Neuro endocrinology letters
Peptides and Ageing
A technology has been developed for manufacturing of biologically active complex peptide preparations from extracts of different tissues. In particular, the pineal preparation (Epithalamin) augments the in vitro outgrowth of explants from the pine...
Khavinson VKh — Neuro endocrinology letters
Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats
The effect of synthetic pineal peptide Epitalon (Ala-Glu-Asp-Gly) on colon carcinogenesis was firstly studied in rats. Eighty 2-month-old outbred male LIO rats were subdivided into four groups and were weekly exposed to five subcutaneous injection...
Anisimov VN, Khavinson VKh, Popovich IG et al. — Cancer letters