Pichia pastoris secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models
Pichia pastoris-secreted delta sleep inducing peptide and crossing the blood-brain barrier peptides (DSIP-CBBBP) fusion peptides holds significant promise for its potential sleep-enhancing and neurotransmitter balancing effects. This study investi...
Mu X, Qu L, Yin L et al. — Frontiers in pharmacology
Delta sleep-inducing peptide (DSIP): a still unresolved riddle
Delta sleep-inducing peptide (DSIP) was isolated from rabbit cerebral venous blood by Schoenenberger-Monnier group from Basel in 1977 and initially regarded as a candidate sleep-promoting factor. However, the link between DSIP and sleep has never ...
Kovalzon VM, Strekalova TV — Journal of neurochemistry
Delta sleep-inducing peptide (DSIP)-like immunoreactivity in gut: coexistence with known peptide hormones
Delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) has previously been demonstrated in brain neurons and in endocrine cells of the pituitary and the adrenal medulla. By means of three different antisera against synthetic DSIP we now desc...
Bjartell A, Ekman R, Hedenbro J et al. — Peptides
DSIP--a tool for investigating the sleep onset mechanism: a review
Delta-Sleep-Inducing Peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals under certain conditions. These effects include modification in thermoregulation, heart rate, blood pressure, pain thresho...
Yehuda S, Carasso RL — The International journal of neuroscience
Delta-sleep-inducing peptide (DSIP): an update
The isolation and characterization of delta-sleep-inducing peptide (DSIP) achieved from 1963 to 1977 were reviewed in 1984. The first reports describing sleep as well as extra-sleep effects of DSIP also were included in that work. Only two years l...
Graf MV, Kastin AJ — Peptides
Delta sleep-inducing peptide (DSIP) stimulates LH release in steroid-primed ovariectomized rats
Delta sleep inducing peptide (DSIP) has been shown to increase sleep in various animals and it is found in various parts of the brain including the hypothalamus. While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect L...
Sahu A, Kalra SP — Life sciences
The effects of delta-sleep-inducing peptide (DSIP) on wakefulness and sleep patterns in the cat
The effect of a single injection of synthetic delta-sleep-inducing peptide (DSIP, 7 nmol/kg) into the lateral ventricle of 10 cats was investigated by monitoring the sleep-wake cycle during an 8 h period. A significant decrease in sleep latency an...
Susić V, Masirević G, Totić S — Brain research
Delta-sleep-inducing peptide (DSIP): a review
Since the turn of the century, it has been postulated that humoral factors induce sleep. Many compounds were proposed as sleep-factors, but only two of the sleep-peptides have been purified to homogeneity and characterized, so far. One of them, DS...
Graf MV, Kastin AJ — Neuroscience and biobehavioral reviews