Optimisation of vitamin D status in global populations
Vitamin D is important for musculoskeletal health. Concentrations of 25-hydroxyvitamin D, the most commonly measured metabolite, vary markedly around the world and are influenced by many factors including sun exposure, skin pigmentation, covering,...
Harvey NC, Ward KA, Agnusdei D et al. — Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
The Importance of Vitamin K and the Combination of Vitamins K and D for Calcium Metabolism and Bone Health: A Review
The aim of the present review is to discuss the roles of vitamin K (phylloquinone or menaquinones) and vitamin K-dependent proteins, and the combined action of the vitamins K and D, for the maintenance of bone health. The most relevant vitamin K-d...
Aaseth JO, Finnes TE, Askim M et al. — Nutrients
Mechanistic Insights and Therapeutic Strategies in Osteoporosis: A Comprehensive Review
Osteoporosis, a metabolic bone disorder characterized by decreased bone mass per unit volume, poses a significant global health burden due to its association with heightened fracture risk and adverse impacts on patients' quality of life. This revi...
Elahmer NR, Wong SK, Mohamed N et al. — Biomedicines
Genomic signaling of vitamin D
It took several hundred million years of evolution, in order to develop the endocrine vitamin D signaling system, which is formed by a nuclear receptor, the transcription factor VDR (vitamin D receptor), its ligand, the vitamin D3 metabolite 1...
Carlberg C — Steroids
Vitamin D: A master example of nutrigenomics
Nutrigenomics attempts to characterize and integrate the relation between dietary molecules and gene expression on a genome-wide level. One of the biologically active nutritional compounds is vitamin D3, which activates via its metabolite 1α...
Carlberg C, Raczyk M, Zawrotna N — Redox biology
Vitamin D metabolites and analytical challenges
Vitamin D is an essential micronutrient for bone health and the general cellular functions of the body. Its insufficiency/deficiency leads to the pathophysiology of disorders like diabetes, cancer, autoimmune, neurodegenerative, and cardiovascular...
Naik M, Kamath U S, Uppangala S et al. — Analytical methods : advancing methods and applications
Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity
Sarcopenic obesity, low muscle mass, and high body fat are growing health concerns in the aging population. This review highlights the need for standardized criteria and explores nutraceuticals as potential therapeutic agents. Sarcopenic obesity i...
Kim YC, Ki SW, Kim H et al. — Nutrients
Vitamin K supplementation and bone mineral density in dialysis: results of the double-blind, randomized, placebo-controlled RenaKvit trial
Vitamin K deficiency is highly prevalent in patients on dialysis and may contribute to their low bone mineral density (BMD) and increased risk of fracture. This study investigated the effect of menaquinone-7 (MK-7) supplementation on BMD in patien...
Levy-Schousboe K, Marckmann P, Frimodt-Møller M et al. — Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Role of vitamins beyond vitamin D3 in bone health and osteoporosis (Review)
The objective of the present review was to summarize the molecular mechanisms associated with the effects of the vitamins A, C, E and K, and group B vitamins on bone and their potential roles in the development of osteoporosis. Epidemiological fin...
Skalny AV, Aschner M, Tsatsakis A et al. — International journal of molecular medicine
Sun Exposure and Vitamin D
Vitamin D is generally accepted in its importance on the regulation of calcium homeostasis and bone metabolism. Moreover, further health effects due to vitamin D are under discussion. In its effect, vitamin D is more like a hormone. In the classic...
Knuschke P — Current problems in dermatology
Vitamin D and Parkinson's Disease
Vitamin D is a fat-soluble secosteroid, traditionally considered a key regulator of bone metabolism, calcium and phosphorous homeostasis. Its action is made possible through the binding to the vitamin D receptor (VDR), after which it directly and ...
Pignolo A, Mastrilli S, Davì C et al. — Nutrients
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials
Vitamin K (VK) as a nutrient, is a cofactor in the carboxylation of osteocalcin (OC), which can bind with hydroxyapatite to promote bone mineralization and increase bone strength. However, some studies have been inconsistent on whether vitamin K2 ...
Ma ML, Ma ZJ, He YL et al. — Frontiers in public health
Vitamin D supplementation during pregnancy: an overview
Examine recent evidence of randomized controlled trials and meta-analyses regarding the effect of maternal vitamin D status and supplementation over obstetrical and offspring outcomes.
Pérez-López FR, Pilz S, Chedraui P — Current opinion in obstetrics & gynecology
An Update on Vitamin D Metabolism
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of li...
Saponaro F, Saba A, Zucchi R — International journal of molecular sciences
The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials
Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality.
Kuang X, Liu C, Guo X et al. — Food & function
Calcium, vitamin D, vitamin K2, and magnesium supplementation and skeletal health
Supplementation with calcium (Ca) and/or vitamin D (vitD) is key to the management of osteoporosis. Other supplements like vitamin K2 (VitK2) and magnesium (Mg) could contribute to the maintenance of skeletal health. This narrative review summariz...
Capozzi A, Scambia G, Lello S — Maturitas
Effects of Vitamin D on Muscle Function and Performance: A Review of Evidence from Randomized Controlled Trials
Systematic review of RCTs examining vitamin D supplementation and muscle function. Found consistent improvements in proximal muscle strength in deficient populations. Effects less clear in vitamin D-replete individuals.
Rejnmark L — Therapeutic Advances in Chronic Disease
Vitamin D, neurosteroids and autism
Vitamin D had been for a long time investigated for its effects on bone metabolism. Recently has been observed that the incidence of some neurodevelopmental disorders (including autism) increases hand in hand with vitamin D deficiency. Indeed, vit...
Máčová L, Bičíková M, Ostatníková D et al. — Physiological research
Vitamin D supplementation guidelines
Research carried out during the past two-decades extended the understanding of actions of vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many pleiotropic actions in organs and tissues in the body. Most observati...
Pludowski P, Holick MF, Grant WB et al. — The Journal of steroid biochemistry and molecular biology
Non-musculoskeletal benefits of vitamin D
The aim of this study is to determine and critically evaluate the plausible relationships of vitamin D with extra-skeletal tissues in humans. Severe vitamin D deficiency results in rickets in children and osteomalacia in adults; these beneficial e...
Wimalawansa SJ — The Journal of steroid biochemistry and molecular biology
PTH and Vitamin D
PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health. PTH and Vitamin D form a tightly controll...
Khundmiri SJ, Murray RD, Lederer E — Comprehensive Physiology
Sunshine and vitamin D
Vitamin D is vital for bone health and its deficiency deemed as a disease of the past has re-emerged as an important health concern. Exposure of the skin to solar ultraviolet B radiation is the major source of vitamin D and only a small proportion...
Saraff V, Shaw N — Archives of disease in childhood
Vitamin D: deficiency, sufficiency and toxicity
The plethora of vitamin D studies over the recent years highlight the pleomorphic effects of vitamin D outside its conventional role in calcium and bone homeostasis. Vitamin D deficiency, though common and known, still faces several challenges amo...
Alshahrani F, Aljohani N — Nutrients
Vitamin K and bone health
Vitamin K has been purported to play an important role in bone health. It is required for the gamma-carboxylation of osteocalcin (the most abundant noncollagenous protein in bone), making osteocalcin functional. There are 2 main forms (vitamin K1 ...
Hamidi MS, Gajic-Veljanoski O, Cheung AM — Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
Vitamin D and the immune system
It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells, and antigen-presenting cells), and these immunologic c...
Aranow C — Journal of investigative medicine : the official publication of the American Federation for Clinical Research
The effect of vitamin D on bone and osteoporosis
The main effect of the active vitamin D metabolite 1,25(OH)2D is to stimulate the absorption of calcium from the gut. The consequences of vitamin D deficiency are secondary hyperparathyroidism and bone loss, leading to osteoporosis and fractures, ...
Lips P, van Schoor NM — Best practice & research. Clinical endocrinology & metabolism
Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis
The effect of the combined administration of vitamin D3 and vitamin K2 on bone mineral density (BMD) of the lumbar spine was examined in postmenopausal women with osteoporosis. Ninety-two osteoporotic women who were more than 5 years after menopau...
Iwamoto J, Takeda T, Ichimura S — Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association